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PROSTIN E2® (dinoprostone) Dosage and Administration

DOSAGE AND ADMINISTRATION

STORE IN A FREEZER NOT ABOVE –20°C (–4°F) BUT BRING TO ROOM TEMPERATURE JUST PRIOR TO USE.

REMOVE FOIL BEFORE USE.

A suppository containing 20 mg of dinoprostone should be inserted high into the vagina. The patient should remain in the supine position for ten minutes following insertion. Additional intravaginal administration of each subsequent suppository should be at 3- to 5-hour intervals until abortion occurs. Within the above recommended intervals administration time should be determined by abortifacient progress, uterine contractility response, and by patient tolerance. Continuous administration of the drug for more than 2 days is not recommended.

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